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CTLA-4 Pathway Is Instrumental in Giant Cell Arteritis.

Paul Régnier,Alexandre Le Joncour,Anna Maciejewski-Duval,Guillaume Darrasse-Jèze,Charles Dolladille,Wouter C Meijers,Lisa Bastarache,Pierre Fouret,Patrick Bruneval, Floriane Arbaretaz,Célia Sayetta,Ana Márquez,Michelle Rosenzwajg,David Klatzmann,Patrice Cacoub,Javid J Moslehi,Joe-Elie Salem,David Saadoun

Circulation research（2023）

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摘要
We highlighted the instrumental role of CTLA-4 immune checkpoint in GCA, which provides a strong rationale for targeting this pathway.
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关键词
giant cell arteritis, humans, immune checkpoint inhibitors, T-lymphocytes, regulatory, vasculitis
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