Increasing autophagy ameliorates all- trans -retinal-activated NLRP3 inflammasomes in human THP-1 macrophages.

Qingqing Xia,Jie Li,Lingmin Zhang,Yingying Zhou,Zaixing Yang,Jing Xie

American journal of translational research（2023）

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摘要

atRAL activates both the NLRP3 inflammasome and autophagy in THP-1 cells, and the increasing level of autophagy leads to the inhibition of excessive NLRP3 inflammasome activation. These findings shed new light on the pathogenesis of age-related retinal degeneration.

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关键词

All-trans-retinal, NLRP3 inflammasome, autophagy, age-related macular degeneration, reactive oxygen species

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