Identification of diagnostic biomarkers in Alzheimer's disease by integrated bioinformatic analysis and machine learning strategies.

Boru Jin,Xiaoqin Cheng,Guoqiang Fei,Shaoming Sang,Chunjiu Zhong

Frontiers in aging neuroscience（2023）

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摘要

The pathways of immune response and oxidative stress can play a crucial role in the pathogenesis of AD. TXNIP, EGR1, and IGFBP5 are useful biomarkers for diagnosing AD and their mRNA level may reflect the development of the disease by correlation with the CDR scores and Breaking staging.

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diagnostic biomarkers,integrated bioinformatic analysis,alzheimers,machine learning

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