Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple-negative breast cancer to immune checkpoint inhibitors.

Xin-Yu Chen,Bin Li,Ye Wang,Juan Jin,Yu Yang,Lei-Huan Huang,Meng-Di Yang,Jian Zhang,Bi-Yun Wang, Zhi-Ming Shao,Ting Ni,Sheng-Lin Huang,Xi-Chun Hu,Zhong-Hua Tao

Cancer communications (London, England)（2023）

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摘要

In AIR epigenetics, low ARID1A expression in TNBC contributed to AIR via the ARID1A/NPM1/PD-L1 axis, leading to poor outcome but sensitivity to ICI treatment.

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关键词

adaptive immune resistance, ARID1A, CD8(+) T cell, PD-L1, triple-negative breast cancer

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