Echinacoside inhibits colorectal cancer metastasis via modulating gut microbiota and suppressing PI3K/AKT signaling pathway.

Jiao Wei,Zongmei Zheng,Xinxin Hou,Fengjing Jia,Yuan Yuan,Fuwen Yuan,Feng He,Liang Hu,Ling Zhao

Journal of ethnopharmacology（2023）

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摘要

This study demonstrated that ECH exhibits oral anti-metastatic efficacy by facilitating butyrate-producing gut bacteria, which downregulates PI3K/AKT signaling and EMT. It hints at a novel role for ECH in CRC therapy.

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