Genomic profiles of renal cell carcinoma in a small Chinese cohort.

Sheng Tai,Dan-Dan Xu,Zhixian Yu,Yu Guan,Shuiping Yin,Jun Xiao, Song Xue,Chaozhao Liang

Frontiers in oncology（2023）

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摘要

Our study revealed that nccRCC is more heterogeneous than ccRCC. For nccRCC patients, the small panel shows a more clear profile of genetic characteristics by replacing MLH3, KMT2D, and CREBBP with ATM, MSH6, BRAF, and KRAS, which may help predict prognosis and make clinical decisions.

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关键词

renal cell carcinoma (RCC), clear cell renal cell carcinoma (ccRCC), non-clear cell renal cell carcinoma (nccRCC), mutation, VHL, FH

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