Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.

Kimberly Z Head,Oluwanifemi E Bolatimi,Tyler C Gripshover,Min Tan,Yan Li,Timothy N Audam,Steven P Jones,Carolyn M Klinge,Matthew C Cave,Banrida Wahlang

Frontiers in gastroenterology (Lausanne, Switzerland)（2023）

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摘要

Overall, the results demonstrated that longer-term PCB exposure worsened TAFLD outcomes independent of HFD feeding and suggests altered energy metabolism as a potential mechanism fueling PCB mediated toxicity without dietary insult. Additional research exploring mechanisms for these longer-term PCB mediated toxicity in TAFLD is warranted.

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Aroclor 1260,PCBs,NAFLD,TAFLD,steatohepatitis,hepatocellular carcinoma

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