Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis.

Myriam Martin,Sara C Nilsson, David Eikrem,Karin Fromell,Carsten Scavenius,Leonie M Vogt,Ewa Bielecka,Jan Potempa,Jan J Enghild,Bo Nilsson,Kristina N Ekdahl,Meliha C Kapetanovic,Anna M Blom

Frontiers in immunology（2023）

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摘要

Citrullination of the C1-INH by recombinant human PAD2 and PAD4 enzymes impaired its ability to inhibit the complement and contact systems . Citrullination seems to render C1-INH more immunogenic, and citrullinated C1-INH might thus be an additional target of the autoantibody response observed in RA patients.

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impaired complement regulation,rheumatoid arthritis

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