Underlying pharmacological mechanisms of psilocin-induced broadband desynchronization and disconnection of EEG in rats.

Filip Tylš,Čestmír Vejmola,Vlastimil Koudelka,Václava Piorecká,Lukáš Kadeřábek, Marcel Bochin,Tomáš Novák,Martin Kuchař,Zdeňka Bendová,Martin Brunovský,Jiří Horáček,Tomáš Pálení Ček

Frontiers in neuroscience（2023）

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摘要

These findings suggest the involvement of all three serotonergic receptors studied as well as the role of dopaminergic mechanisms in power spectra/current density with only the 5-HT receptor being effective in both studied metrics. This opens an important discussion on the role of other than 5-HT-dependent mechanisms underlying the neurobiology of psychedelics.

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关键词

serotonergic psychedelics, psilocybin, psilocin, model of acute psychosis, quantitative EEG, power spectra, phase-lagged coherence, global functional connectivity (GFC)

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