Zanthoxylum bungeanum amides ameliorates nonalcoholic fatty liver via regulating gut microbiota and activating AMPK/Nrf2 signaling.

Wei Peng,Cheng-Xun He,Ruo-Lan Li,Die Qian,Ling-Yu Wang,Wen-Wen Chen,Qing Zhang,Chun-Jie Wu

Journal of ethnopharmacology（2023）

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摘要

Collectively, our results suggested AZB can improve NAFL, which could reduce body weight, reverse liver lesions and fat accumulation, improve oxidative stress in liver tissues of HFD mice. Furthermore, the mechanisms are related to increase of the abundance of high-producing bacteria for SCFAs (e.g. Allobaculum, Bacteroides and Dubosiella) to activate AMPK/Nrf2 signaling.

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关键词

Nonalcoholic fatty liver, Zanthoxylum bungeanum maxim, Gut microbiota, AMPK, Nrf2 signaling, Short-chain fatty acids

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