Inhibition of Nuclear Receptor Related Orphan Receptor γ Ameliorates Mechanical Hypersensitivity Through the Suppression of Spinal Microglial Activation

Norimitsu Morioka,Maho Tsuruta, Nao Masuda,Kiichi Yamano,Manaya Nakano,Takahiro Kochi,Yoki Nakamura,Kazue Hisaoka-Nakashima

Neuroscience（2023）

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摘要

•RORγ mRNA was expressed in cultured rat spinal microglia.•RORγ inverse agonist SR2211 prevented upregulation of cytokines in microglia.•Intrathecal SR2211 treatment prevented LPS-induced mechanical hypersensitivity.•Intrathecal SR2211 treatment prevented PSNL-induced mechanical hypersensitivity.•Inhibition of RORγ prevented LPS- and PSNL-induced Iba1 expression in spinal cord.

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关键词

microglia,retinoic acid related orphan receptor,inflammation,neuropathic pain,proinflammatory cytokine,spinal cord

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