Tumor size is the most significant risk factor for local recurrence in dermatofibrosarcoma protuberans: A large-scale retrospective cohort analysis.

To the Editor: Dermatofibrosarcoma protuberans (DFSP) is a rare, aggressive soft tissue sarcoma that affects the dermis, subcutaneous fat, and, in rare cases, muscle and fascia. Although, the metastatic rate of DFSP is low, the local recurrence rate is estimated to range from 2% to 21%. 1 Huis In ’t Veld E.A. van Coevorden F. Grünhagen D.J. et al. Outcome after surgical treatment of dermatofibrosarcoma protuberans: is clinical follow-up always indicated?. Cancer. 2019; 125: 735-741https://doi.org/10.1002/cncr.31924 Crossref PubMed Scopus (26) Google Scholar Negative surgical margins are considered to be the most important prognostic factor for DFSP, as local recurrence can predispose to distant metastases. 2 Hao X. Billings S.D. Wu F. et al. Dermatofibrosarcoma protuberans: update on the diagnosis and treatment. J Clin Med. 2020; 9: 1752https://doi.org/10.3390/jcm9061752 Crossref PubMed Scopus (49) Google Scholar Previous research on DFSP prognosis is centered on small cohorts and case series.