Downregulation of BDNF-TrkB signaling may contribute to the colonic motility disorders in mice with streptozocin-induced diabetes.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society(2023)

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摘要
Downregulation of BDNF/TrkB signaling and reduced SP release from the colon may contribute to the colonic hypomotility associated with type 1 diabetes. Brain-derived neurotrophic factor supplementation may have therapeutic potential for diabetes-related constipation.
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关键词
brain-derived neurotrophic factor, colon, diabetes mellitus, motility, substance P
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