Efficient removal of antibodies to adeno-associated viruses by immunoadsorption.

Simone Boedecker-Lips, Andreas Judel,Stefan Holtz, Magnus Mayer,Pascal Klimpke,Daniel Kraus,Thomas Schreiner, Bernhard Gerstmayer, Klaus Eulitz,Magnus Christopher Mayer,Julia Weinmann-Menke

Journal of clinical apheresis（2023）

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摘要

In summary, IA may represent a safe strategy to precondition patients with pre-existing anti-AAV antibodies to make this population eligible for an effective AAV-based gene therapy.

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关键词

adeno-associated viral vector-based gene therapies, adeno-associated virus, antibody, immunoadsorption, immunoglobulin, monogenetic diseases, plasmapheresis

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