Upregulated LncRNA H19 Sponges MiR-106a-5p and Contributes to Aldosterone-Induced Vascular Calcification via Activating the Runx2-Dependent Pathway.

Xiong-Zhi Li, Zhuo-Chao Xiong,Shao-Ling Zhang,Qing-Yun Hao,Zhao-Yu Liu,Hai-Feng Zhang,Jing-Feng Wang,Jing-Wei Gao,Pin-Ming Liu

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Our study clarifies a novel mechanism by which upregulation of H19 contributes to aldosterone-MR complex-promoted Runx2-dependent VSMC osteogenic differentiation and VC through sponging miR-106a-5p. These findings highlight a potential therapeutic target for aldosterone-induced VC.

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关键词

aldosterone, differentiation, transcriptional activity, upregulation, vascular calcification

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