Sphingosylphosphorylcholine inhibits plasma cell differentiation and ameliorates experimental autoimmune encephalomyelitis.

Byunghyun Park,Yu Sun Jeong, Wonseok Hu,Mingyu Lee,Ji Cheol Kim,Geon Ho Bae,Yong-Soo Bae,Yoe-Sik Bae

Frontiers in immunology（2023）

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摘要

Collectively, we demonstrate that SPC strongly inhibits plasma cell differentiation, which is mediated by S1PR3. SPC also elicits therapeutic outcomes against EAE, an experimental model of MS, suggesting SPC as a new material to control MS.

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关键词

sphingosylphosphorylcholine, plasma cells, S1PR3, experimental autoimmune encephalomyelitis, multiple sclerosis

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