Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis.

Daniel B Hoffmann,Christoph Derout,Max Müller-Reiter,Kai O Böker,Arndt F Schilling,Paul J Roch,Wolfgang Lehmann,Dominik Saul,Thelonius Hawellek,Stefan Taudien,Stephan Sehmisch,Marina Komrakova

Journal of bone and mineral metabolism（2023）

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摘要

Ligandrol at high dose showed a subtle anabolic effect on structural properties without any improvement in biomechanical properties of osteoporotic bones. Considering side effects of ligandrol at this dose, its further investigation for the therapy of postmenopausal osteoporosis should be reevaluated.

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关键词

Ligandrol, Selective androgen receptor modulator, Osteoporosis, Rat model

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