Targeting the Clear Cell Sarcoma Oncogenic Driver Fusion Gene EWSR1::ATF1 by HDAC Inhibition.

Hirokazu Mae,Hidetatsu Outani,Yoshinori Imura,Ryota Chijimatsu,Akitomo Inoue, Yuki Kotani,Naohiro Yasuda,Sho Nakai,Takaaki Nakai,Satoshi Takenaka,Seiji Okada

Cancer research communications（2023）

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摘要

This study reveals the epigenetic and transcriptional suppression mechanism of the fusion oncogene in clear cell sarcoma by histone deacetylase inhibitor treatment as well as identifying SOX10 as a transcription factor that regulates expression.

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关键词

clear cell sarcoma,ewsr1atf1,gene

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