Lestaurtinib inhibits Citron kinase activity and medulloblastoma growth through induction of DNA damage, apoptosis and cytokinesis failure.

Gianmarco Pallavicini,Giorgia Iegiani,Roberta Parolisi, Alessia Ferraro,Francesca Garello,Valeria Bitonto,Enzo Terreno,Marta Gai,Ferdinando Di Cunto

Frontiers in oncology（2023）

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摘要

Our data indicate that Lestaurtinib produces in MB cells poly-pharmacological effects extending beyond the inhibition of its validated targets, supporting the possibility of repositioning this drug for MB treatment.

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关键词

Lestaurtinib, CitK, drug repurposing, medulloblastoma, preclinical studies

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