First-in-Human Phase 1 Study of a B Cell- and Monocyte-Based Immunotherapeutic Vaccine Against HER2-Positive Advanced Gastric Cancer.

Minkyu Jung,Jii Bum Lee,Hyo Song Kim,Woo Sun Kwon,Hyun Ok Kim,Sinyoung Kim,Myunghwan Park,Wuhyun Kim,Ki-Young Choi,Taegwon Oh,Chang-Yuil Kang,Hyun Cheol Chung,Sun Young Rha

Cancer research and treatment（2023）

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摘要

BVAC-B monotherapy had a safe toxicity profile with limited clinical activity; however, it activated immune cells in heavily pretreated patients with HER2-positive gastric cancer. Earlier treatment with BVAC-B and combination therapy is warranted for evaluation of clinical efficacy.

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