Nucleic-Acid-Templated Synthesis of Smart Polymer Vectors for Gene Delivery.

Nucleic acids are information-rich and readily available biomolecules which can be used to template the polymerization of synthetic macromolecules. Here, we highlight the control over the size, composition and sequence one can nowadays obtain using this methodology. We also showcase how templated processes exploiting dynamic covalent polymerization can, in return, result in therapeutic nucleic acids fabricating their own dynamic delivery vector - a biomimicking concept that can provide original solutions for gene therapies.