Gold catalyzed hydrofluorination of propargyl alcohols promoted by fluorine-hydrogen bonding.

The hydroxyl group was discovered to promote gold catalyzed hydrofluorination of alkynes hydrogen bonding interaction. Based on this strategy, propargyl alcohols could be hydrofluorinated smoothly using EtN·3HF under acidic additive-free conditions, which provided a straightforward alternative protocol for the synthesis of 3-fluoroallyl alcohols.