Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival.

Anna Morra,Maartje A C Schreurs,Irene L Andrulis,Hoda Anton-Culver,Annelie Augustinsson,Matthias W Beckmann,Sabine Behrens,Stig E Bojesen,Manjeet K Bolla,Hiltrud Brauch,Annegien Broeks,Saundra S Buys,Nicola J Camp,Jose E Castelao,Melissa H Cessna,Jenny Chang-Claude,Wendy K Chung,Sarah V Colonna,Fergus J Couch,Angela Cox,Simon S Cross,Kamila Czene,Mary B Daly,Joe Dennis,Peter Devilee,Thilo Dörk,Alison M Dunning,Miriam Dwek,Douglas F Easton,Diana M Eccles,Mikael Eriksson,D Gareth Evans,Peter A Fasching,Tanja N Fehm,Jonine D Figueroa,Henrik Flyger,Marike Gabrielson,Manuela Gago-Dominguez,Montserrat García-Closas,José A García-Sáenz,Jeanine Genkinger,Felix Grassmann,Melanie Gündert,Eric Hahnen,Christopher A Haiman,Ute Hamann,Patricia A Harrington,Jaana M Hartikainen,Reiner Hoppe,John L Hopper,Richard S Houlston,Anthony Howell,Anna Jakubowska,Wolfgang Janni,Helena Jernström,Esther M John,Nichola Johnson,Michael E Jones,Vessela N Kristensen,Allison W Kurian,Diether Lambrechts,Loic Le Marchand,Annika Lindblom,Jan Lubiński,Michael P Lux,Arto Mannermaa,Dimitrios Mavroudis,Anna Marie Mulligan,Taru A Muranen,Heli Nevanlinna,Ines Nevelsteen,Patrick Neven,William G Newman,Nadia Obi,Kenneth Offit,Andrew F Olshan,Tjoung-Won Park-Simon,Alpa V Patel,Paolo Peterlongo,Kelly-Anne Phillips,Dijana Plaseska-Karanfilska,Eric C Polley,Nadege Presneau,Katri Pylkäs,Brigitte Rack,Paolo Radice,Muhammad U Rashid,Valerie Rhenius,Mark Robson,Atocha Romero,Emmanouil Saloustros,Elinor J Sawyer,Rita K Schmutzler,Sabine Schuetze,Christopher Scott,Mitul Shah,Snezhana Smichkoska,Melissa C Southey,William J Tapper,Lauren R Teras,Rob A E M Tollenaar,Katarzyna Tomczyk,Ian Tomlinson,Melissa A Troester,Celine M Vachon,Elke M van Veen,Qin Wang,Camilla Wendt,Hans Wildiers,Robert Winqvist,Argyrios Ziogas,Per Hall,Paul D P Pharoah,Muriel A Adank,Antoinette Hollestelle,Marjanka K Schmidt,Maartje J Hooning

Cancer medicine（2023）

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摘要

Systemic therapy was associated with reduced CBC risk irrespective of CHEK2 c.1100delC status. Moreover, CHEK2 c.1100delC carriers had shorter BCSS, which appears not to be fully explained by their CBC risk.

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关键词

contralateral breast cancer risk,breast cancer risk,radiotherapy,cancer-specific

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