Trends in adverse drug reactions related to oral weak opioid analgesics in therapeutic use in adults: A 10-year French vigilances retrospective study.

Weniko Caré,Sylvine Pinel,Laurène Dufayet,Jérôme Langrand,Joëlle Micallef,Dominique Vodovar

Fundamental & clinical pharmacology（2023）

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摘要

ADRs mostly occurred among young women using tramadol, without significant variation in the number of reported cases over time. Serious ADRs were more frequently reported to the Pharmacovigilance database, particularly for codeine. Women seemed to be at greater risk of ADRs.

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关键词

codeine, drug-related side effects and adverse reactions, opioid analgesics, pharmacovigilance, Poison Control Centers, tramadol

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