Comparative chemical genomics in Babesia species identifies the alkaline phosphatase phoD as a novel determinant of resistance.

Use of two species for evolution identifies a high confidence locus associated with resistance Resistance mutation in phoD was validated using reverse genetics in Perturbation of phoD using function genetics results in changes in the level of resistance to MMV019266Epitope tagging reveals localization to the ER/apicoplast, a conserved localization with a similar protein in diatoms Together, phoD is a novel resistance determinant in multiple .