Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.

Jennifer E Huffman,Jayna Nicolas,Julie Hahn,Adam S Heath,Laura M Raffield,Lisa R Yanek,Jennifer A Brody,Florian Thibord,Laura Almasy,Traci M Bartz,Lawrence F Bielak,Russell P Bowler,Germán D Carrasquilla,Daniel I Chasman,Ming-Huei Chen,David B Emmert,Mohsen Ghanbari,Jeffery Haessle,Jouke-Jan Hottenga,Marcus E Kleber,Ngoc-Quynh Le,Jiwon Lee,Joshua P Lewis,Ruifang Li-Gao,Jian'an Luan,Anni Malmberg,Massimo Mangino,Riccardo E Marioni,Angel Martinez-Perez,Nathan Pankratz,Ozren Polasek,Anne Richmond,Benjamin At Rodriguez,Jerome I Rotter,Maristella Steri,Pierre Suchon,Stella Trompet,Stefan Weiss,Marjan Zare,Paul Auer,Michael H Cho,Paraskevi Christofidou,Gail Davies,Eco de Geus,Jean-François Deleuze,Graciela E Delgado,Lynette Ekunwe,Nauder Faraday,Martin Gögele,Andreas Greinacher,Gao He,Tom Howard, Peter K Joshi,Tuomas O Kilpeläinen,Jari Lahti,Allan Linneberg,Silvia Naitza,Raymond Noordam,Ferran Paüls-Vergés,Stephen S Rich,Frits R Rosendaal,Igor Rudan,Kathleen A Ryan,Juan Carlos Souto,Frank Ja van Rooij,Heming Wang,Wei Zhao,Lewis C Becker,Andrew Beswick,Michael R Brown,Brian E Cade,Harry Campbell,Kelly Cho,James D Crapo,Joanne E Curran,Moniek Pm de Maat,Margaret Doyle,Paul Elliott, James S Floyd,Christian Fuchsberger,Niels Grarup,Xiuqing Guo,Sarah E Harris,Lifang Hou,Ivana Kolcic,Charles Kooperberg,Cristina Menni,Matthias Nauck,Jeffrey R O'Connell,Valeria Orrù, Bruce M Psaty,Katri Räikkönen,Jennifer A Smith,Jose Manuel Soria,David J Stott,Astrid van Hylckama Vlieg,Hugh Watkins,Gonneke Willemsen,Peter Wilson,Yoav Ben-Shlomo,John Blangero, Dorret Boomsma,Simon R Cox,Abbas Dehghan,Johan G Eriksson,Edoardo Fiorillo,Myriam Fornage,Torben Hansen,Caroline Hayward,M Arfan Ikram,J Wouter Jukema,Sharon Lr Kardia,Leslie A Lange,Winfried März,Rasika A Mathias, Braxton D Mitchell,Dennis O Mook-Kanamori,Pierre-Emmanuel Morange,Oluf Pedersen,Peter P Pramstaller,Susan Redline,Alexander Reiner,Paul M Ridker,Edwin K Silverman,Tim D Spector,Uwe Völker,Nick Wareham, James F Wilson,Jie Yao,David-Alexandre Trégouët,Andrew D Johnson,Alisa S Wolberg,Paul S de Vries,Maria Sabater-Lleal,Alanna C Morrison,Nicholas L Smith

medRxiv : the preprint server for health sciences（2023）

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摘要

Largest and most diverse genetic study of plasma fibrinogen identifies 54 regions (18 novel), housing 69 conditionally distinct variants (20 novel).Sufficient power achieved to identify signal driven by African population variant.Links to (1) liver enzyme, blood cell and lipid genetic signals, (2) liver regulatory elements, and (3) thrombotic and inflammatory disease.

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