Development of a Translational Autologous Microthrombi-Induced MINOCA Pig Model.

HomeCirculation ResearchVol. 133, No. 3Development of a Translational Autologous Microthrombi-Induced MINOCA Pig Model No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextDevelopment of a Translational Autologous Microthrombi-Induced MINOCA Pig Model Nikola Cesarovic, Miriam Weisskopf, Thorald Stolte, Nina Trimmel, Melanie M. Hierweger, Tobias Hoh, Jasper Iske, Conny Waschkies, Jia Lu Chen, Eva van Gelder, Andrea Leuthardt, Lukas Glaus, Yannick Rösch, Christian T. Stoeck, Petra Wolint, Dominik Obrist, Sebastian Kozerke, Volkmar Falk and Maximilian Y. Emmert Nikola CesarovicNikola Cesarovic Correspondence to: Nikola Cesarovic, PhD, Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland. Email E-mail Address: [email protected] https://orcid.org/0000-0001-6744-2928 Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland (N.C., T.S., E.v.G., P.W., V.F., L.G.). Deutsches Herzzentrum der Charite (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany (N.C., J.I., V.F., M.Y.E.). *N. Cesarovic and M. Weisskopf contributed equally. Search for more papers by this author , Miriam WeisskopfMiriam Weisskopf https://orcid.org/0000-0001-6012-3051 Center for Preclinical Development, University Hospital of Zurich, University of Zurich, Switzerland (M.W., N.E.T., M.M.H., A.L., C.T.S.). *N. Cesarovic and M. Weisskopf contributed equally. Search for more papers by this author , Thorald StolteThorald Stolte https://orcid.org/0000-0001-9840-7818 Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland (N.C., T.S., E.v.G., P.W., V.F., L.G.). Search for more papers by this author , Nina TrimmelNina Trimmel https://orcid.org/0000-0003-2514-0790 Center for Preclinical Development, University Hospital of Zurich, University of Zurich, Switzerland (M.W., N.E.T., M.M.H., A.L., C.T.S.). Search for more papers by this author , Melanie M. HierwegerMelanie M. Hierweger https://orcid.org/0009-0001-5972-5167 Center for Preclinical Development, University Hospital of Zurich, University of Zurich, Switzerland (M.W., N.E.T., M.M.H., A.L., C.T.S.). Search for more papers by this author , Tobias HohTobias Hoh https://orcid.org/0000-0002-1391-6347 Institute for Biomedical Engineering, University and ETH Zurich, Switzerland (T.H., C.W., C.T.S., S.K.). Search for more papers by this author , Jasper IskeJasper Iske https://orcid.org/0000-0001-8647-3092 Deutsches Herzzentrum der Charite (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany (N.C., J.I., V.F., M.Y.E.). Search for more papers by this author , Conny WaschkiesConny Waschkies Institute for Biomedical Engineering, University and ETH Zurich, Switzerland (T.H., C.W., C.T.S., S.K.). Search for more papers by this author , Jia Lu ChenJia Lu Chen https://orcid.org/0000-0002-1048-6046 Department of Mechanical and Process Engineering, University and ETH Zurich, Switzerland (J.L.C.). Search for more papers by this author , Eva van GelderEva van Gelder https://orcid.org/0009-0000-8948-7190 Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland (N.C., T.S., E.v.G., P.W., V.F., L.G.). Search for more papers by this author , Andrea LeuthardtAndrea Leuthardt https://orcid.org/0000-0002-8520-4103 Center for Preclinical Development, University Hospital of Zurich, University of Zurich, Switzerland (M.W., N.E.T., M.M.H., A.L., C.T.S.). Search for more papers by this author , Lukas GlausLukas Glaus https://orcid.org/0000-0002-1565-9188 Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland (N.C., T.S., E.v.G., P.W., V.F., L.G.). Search for more papers by this author , Yannick RöschYannick Rösch https://orcid.org/0000-0001-7284-3072 ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland (Y.R., D.O.). Search for more papers by this author , Christian T. StoeckChristian T. Stoeck https://orcid.org/0000-0001-8670-0929 Center for Preclinical Development, University Hospital of Zurich, University of Zurich, Switzerland (M.W., N.E.T., M.M.H., A.L., C.T.S.). Institute for Biomedical Engineering, University and ETH Zurich, Switzerland (T.H., C.W., C.T.S., S.K.). Search for more papers by this author , Petra WolintPetra Wolint Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland (N.C., T.S., E.v.G., P.W., V.F., L.G.). Search for more papers by this author , Dominik ObristDominik Obrist https://orcid.org/0000-0002-6062-9076 ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland (Y.R., D.O.). Search for more papers by this author , Sebastian KozerkeSebastian Kozerke Institute for Biomedical Engineering, University and ETH Zurich, Switzerland (T.H., C.W., C.T.S., S.K.). Search for more papers by this author , Volkmar FalkVolkmar Falk https://orcid.org/0000-0002-7911-8620 Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland (N.C., T.S., E.v.G., P.W., V.F., L.G.). Deutsches Herzzentrum der Charite (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany (N.C., J.I., V.F., M.Y.E.). Charité-Universitätsmedizin Berlin, Germany (V.F., M.Y.E.). Deutsches Zentrum für Herz-Kreislaufforschung, Partner Site Berlin, Germany (V.F., M.Y.E.). Search for more papers by this author and Maximilian Y. EmmertMaximilian Y. Emmert Deutsches Herzzentrum der Charite (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany (N.C., J.I., V.F., M.Y.E.). Charité-Universitätsmedizin Berlin, Germany (V.F., M.Y.E.). Deutsches Zentrum für Herz-Kreislaufforschung, Partner Site Berlin, Germany (V.F., M.Y.E.). Institute for Regenerative Medicine (IREM), University of Zurich, Switzerland (M.Y.E.). Search for more papers by this author Originally published3 Jul 2023https://doi.org/10.1161/CIRCRESAHA.123.322850Circulation Research. 2023;133:291–293is related toMeet the First AuthorsFootnotes*N. Cesarovic and M. Weisskopf contributed equally.For Sources of Funding and Disclosures, see page 293.Correspondence to: Nikola Cesarovic, PhD, Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland. Email nikola.cesarovic@hest.ethz.chREFERENCES1. Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, De Caterina R, Zimarino M, Roffi M, Kjeldsen K, et al; WG on Cardiovascular Pharmacotherapy. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries.Eur Heart J. 2017; 38:143–153. doi: 10.1093/eurheartj/ehw149CrossrefMedlineGoogle Scholar2. Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF. Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries.Circulation. 2015; 131:861–870. doi: 10.1161/CIRCULATIONAHA.114.011201LinkGoogle Scholar3. Pellegrini D, Kawakami R, Guagliumi G, Sakamoto A, Kawai K, Gianatti A, Nasr A, Kutys R, Guo L, Cornelissen A, et al. Microthrombi as a major cause of cardiac injury in COVID-19 a pathologic study.Circulation. 2021; 143:1031–1042. doi: 10.1161/CIRCULATIONAHA.120.051828LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesMeet the First AuthorsCirculation Research. 2023;133:198-199 July 21, 2023Vol 133, Issue 3 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.322850PMID: 37395118 Originally publishedJuly 3, 2023 Keywordsmodels, animalMINOCAhemodynamicscathetersbiomarkersangiographymyocardial infarctionPDF download Advertisement SubjectsAnimal Models of Human DiseaseCoronary Artery DiseaseTranslational Studies