Depression with novel antibodies against Bergmann glia in the cerebrospinal fluid.

Autoimmune astrocytopathy associated with anti-GFAP autoantibodies usually manifests with meningoencephalitis. Here, the first patients with isolated psychiatric syndromes and anti-astrocytic autoantibodies are presented. Patient 1 presented with depression, patient 2 with psychosis. Both patients were found to have novel anti-astrocytic autoantibodies (“GFAP-like”) in their cerebrospinal fluid (CSF) using indirect-immunofluorescence on unfixed murine brain sections; testing for well-characterized anti-GFAP autoantibodies was negative. In patient 1, astrocytic staining was mainly limited to glia limitans, in patient 2, a widespread astrocytic staining was identified. Only patient 1 showed improvement using glucocorticosteroids. These cases suggest an expansion of the clinical spectrum for autoimmune astrocytopathy.