Descriptions and Determinants of N-Terminal Pro-B-Type Natriuretic Peptide in Pediatric CKD: The Chronic Kidney Disease in Children (CKiD) Study.

The serum biomarker, N-terminal pro-B-type natriuretic peptide (NT-proBNP), is released by cardiomyocytes primarily in response to mechanical stress or stretch. NT-proBNP is frequently assessed in adults with chronic kidney disease (CKD) to gain insights into disease mechanisms, improve risk stratification, and guide therapy 1 Colbert G. Jain N. de Lemos J.A. Hedayati S.S. Utility of traditional circulating and imaging-based cardiac biomarkers in patients with predialysis CKD. Clin J Am Soc Nephrol. 2015; 10: 515-529https://doi.org/10.2215/cjn.03600414 Crossref PubMed Scopus (0) Google Scholar . However, NT-proBNP is poorly described in pediatric CKD. Therefore, we sought to define the distribution and clinical determinants of NT-proBNP in a large, diverse, and well-phenotyped pediatric CKD cohort.