Optimizing the number of variants tracked to follow disease burden with circulating tumor DNA assays in metastatic colorectal cancer.

Mélina Boutin,James T Topham,Harriet Feilotter,Hagen F Kennecke,Félix Couture,Mohammed Harb, Peter Kavan,Scott Berry,Howard J Lim,John R Goffin,Chaudhary Ahmad, Anthony Lott,Daniel J Renouf,Derek J Jonker,Dongsheng Tu,Chris J O'Callaghan,Eric X Chen,Jonathan M Loree

Therapeutic advances in medical oncology（2023）

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摘要

While increasing panel breadth beyond two tracked variants improved variant re-detection in ctDNA samples from patients with treatment refractory mCRC, increases beyond four tracked variants yielded no significant improvement in variant re-detection.

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关键词

circulating tumor DNA, colorectal cancer, ctDNA panel breadth, number of variants tracked, monitoring tumor burden

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