The therapeutic mechanism of transcranial iTBS on nerve regeneration and functional recovery in rats with complete spinal cord transection.

Jia-Lin Liu,Shuai Wang,Zheng-Hong Chen,Rong-Jie Wu,Hai-Yang Yu,Shang-Bin Yang,Jing Xu,Yi-Nan Guo,Ying Ding,Ge Li,Xiang Zeng,Yuan-Huan Ma,Yu-Lai Gong,Chuang-Ran Wu,Li-Xin Zhang,Yuan-Shan Zeng,Bi-Qin Lai

Frontiers in immunology（2023）

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摘要

Neuronal activation and neural tracing further verified that iTBS had the potential to provide neuroprotective effects during the early stages of SCI and induce regeneration effects related to the descending motor pathways (CST, 5-HT and LDPT). Furthermore, our results revealed key relationships between neural pathway activation, neuroimmune regulation, neuroprotection and axonal regeneration, as well as the interaction network of key genes.

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关键词

spinal cord injury, intermittent theta-burst stimulation (iTBS), nerve regeneration, synaptic plasticity, motor pathway, neuroprotection

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