Chronic obstructive pulmonary disease alters the genetic landscape and tumor immune microenvironment in lung cancer patients.

Qiurui Zhang,Xijia Feng,Weiting Hu,Chengqiang Li,Debin Sun,Zhao Peng,Shengzhou Wang,Hecheng Li,Min Zhou

Frontiers in oncology（2023）

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摘要

Our study revealed different genetic aberrations and pathways, higher neoantigen burden, and higher level of CD68+ macrophages and CD8+ T lymphocytes in lung cancer patients with COPD. Our investigation implies that the existence of COPD should be considered and immunotherapy is a potential choice when treating lung cancer patients with COPD.

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lung cancer,lung cancer patients,chronic obstructive pulmonary disease,immune microenvironment

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