Mutational pattern off homologous recombination repair (HRR)-related genes in upper tract urothelial carcinoma.

Kaiwei Yang,Wei Yu,Huanhuan Liu,Feng Lou,Shanbo Cao,Huina Wang,Zhisong He

Cancer medicine（2023）

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摘要

Our results imply that the detection of HRR gene mutations can predict recurrence in patients with UC. In addition, this study provides a path to explore the role of HRR-directed therapies, including PARPis, chemotherapy, and immunotherapy.

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关键词

homologous recombination repair (HRR), molecular mechanism, prognosis, tumor immune profile, upper tract urothelial carcinoma (UTUC)

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