Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease.

HomeCirculation: Genomic and Precision MedicineAhead of PrintChildhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease No AccessResearch ArticleRequest AccessAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessChildhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease Gabrielle Norrish, Vidthya Kadirrajah, Ella Field, Kathleen Dady, Jennifer Tollit, Karen McLeod, Ruth McGowan, Elena Cervi and Juan Pablo Kaski Gabrielle NorrishGabrielle Norrish https://orcid.org/0000-0003-2064-237X Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom (G.N., E.F., K.D., J.T., E.C., J.P.K.). University College London Institute of Cardiovascular Science, United Kingdom (G.N., V.K., E.F., J.T., E.C., J.P.K.). Search for more papers by this author , Vidthya KadirrajahVidthya Kadirrajah University College London Institute of Cardiovascular Science, United Kingdom (G.N., V.K., E.F., J.T., E.C., J.P.K.). Search for more papers by this author , Ella FieldElla Field https://orcid.org/0000-0002-0808-2763 Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom (G.N., E.F., K.D., J.T., E.C., J.P.K.). University College London Institute of Cardiovascular Science, United Kingdom (G.N., V.K., E.F., J.T., E.C., J.P.K.). Search for more papers by this author , Kathleen DadyKathleen Dady Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom (G.N., E.F., K.D., J.T., E.C., J.P.K.). Search for more papers by this author , Jennifer TollitJennifer Tollit Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom (G.N., E.F., K.D., J.T., E.C., J.P.K.). University College London Institute of Cardiovascular Science, United Kingdom (G.N., V.K., E.F., J.T., E.C., J.P.K.). Search for more papers by this author , Karen McLeodKaren McLeod Department of Pediatric Cardiology, Royal Hospital for Children, Glasgow, United Kingdom (KML) Search for more papers by this author , Ruth McGowanRuth McGowan https://orcid.org/0000-0002-2188-2239 West of Scotland Centre for Genomic Medicine, Glasgow, United Kingdom (R.M.G.). Search for more papers by this author , Elena CerviElena Cervi https://orcid.org/0000-0003-2612-1014 Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom (G.N., E.F., K.D., J.T., E.C., J.P.K.). University College London Institute of Cardiovascular Science, United Kingdom (G.N., V.K., E.F., J.T., E.C., J.P.K.). Search for more papers by this author and Juan Pablo KaskiJuan Pablo Kaski Correspondence to: Juan Pablo Kaski, MD(Res), FRCP, FESC, Centre for Pediatric Inherited and Rare Cardiovascular Disease, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital, London, WC1N 1DZ, United Kingdom. Email E-mail Address: [email protected] https://orcid.org/0000-0002-0014-9927 Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, United Kingdom (G.N., E.F., K.D., J.T., E.C., J.P.K.). University College London Institute of Cardiovascular Science, United Kingdom (G.N., V.K., E.F., J.T., E.C., J.P.K.). Search for more papers by this author Originally published30 Jun 2023https://doi.org/10.1161/CIRCGEN.123.004118Circulation: Genomic and Precision Medicine. 2023;0:e004118FootnotesFor Sources of Funding and Disclosures, see page XXX.Correspondence to: Juan Pablo Kaski, MD(Res), FRCP, FESC, Centre for Pediatric Inherited and Rare Cardiovascular Disease, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital, London, WC1N 1DZ, United Kingdom. Email j.[email protected]ac.uk eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCGEN.123.004118PMID: 37387224 Originally publishedJune 30, 2023 Keywordsdyspneamyosin-binding protein Csyncopeincidencemyosin heavy chainPDF download Advertisement SubjectsCardiomyopathyGenetic, Association StudiesGenetics