ALKBH5/YTHDF2-mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin neddylation.

Yingjie Shao, Zhenhua Liu,Xing Song,Rui Sun,You Zhou,Dachuan Zhang,Huihui Sun,Junchao Huang,Chenxi Wu,Wendong Gu,Xiao Zheng,Jingting Jiang

Clinical and translational medicine（2023）

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摘要

We identified and characterised circAFF2 as a novel m6A-modified circRNA and validated the ALKBH5/YTHDF2/circAFF2/Cullin-NEDD8 axis as a potential radiotherapy target for CRC.

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关键词

circaff2 enhances radiosensitivity,colorectal cancer

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