Model-informed dose optimisation of polymyxin-rifampicin combination therapy against multidrug-resistant Acinetobacter baumannii

Jinxin Zhao,Yan Zhu,Mei-Ling Han,Jing Lu,Heidi H. Yu,Hasini Wickremasinghe,Qi Tony Zhou,Phillip Bergen,Gauri Rao,Tony Velkov,Yu-Wei Lin,Jian Li

International journal of antimicrobial agents（2023）

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摘要

•Polymyxin B and rifampicin can synergistically kill Acinetobacter baumannii.•The semi-mechanistic pharmacokinetic/pharmacodynamic model aids dose optimisation.•Simulations with clinically utilised regimens confirmed its therapeutic potential.

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关键词

Polymyxin,Rifampicin,Multidrug-resistant Acinetobacter baumannii,Pharmacokinetics/pharmacodynamics,Model-informed dose optimisation,Semi-mechanistic PK/PD model

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