Family environment and polygenic risk in the bipolar high-risk context.

Emma K Stapp,Janice M Fullerton,Rashelle J Musci,Peter P Zandi,Melvin G McInnis,Philip B Mitchell,Leslie A Hulvershorn,Neera Ghaziuddin,Gloria Roberts, Alessandra G Ferrera,John I Nurnberger,Holly C Wilcox

JCPP advances（2023）

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摘要

The data suggest that the relationship of BD-PRS and offspring liability for BD differed between well-functioning versus high-conflict FE, potentially in line with a multifactorial liability threshold model and supporting future study of and interventions improving family dynamics.

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