Factor H preserves alternative complement function during ARDS, linked to improved survival.

William Bain,Mohammadreza Tabary,Sara R Moore,Xiaojing An,Georgios D Kitsios,Bryan J McVerry,Prabir Ray,Anuradha Ray,Rama K Mallampalli,Viviana P Ferreira,Janet S Lee,S Mehdi Nouraie

ERJ open research（2023）

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摘要

Relative factor H deficiency, higher Ba:B and C3a:C3 ratios and lower factor B and C3 levels suggest a subset of ARDS with complement factor exhaustion, impaired alternative pathway function, and increased mortality, that may be amenable to therapeutic targeting.

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关键词

alternative complement function,ards,survival,factor

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