Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment.

Aki Morikawa,Jinju Li,Peter Ulintz,Xu Cheng,Athena Apfel,Dan Robinson, Alex Hopkins,Chandan Kumar-Sinha,Yi-Mi Wu,Habib Serhan,Kait Verbal,Dafydd Thomas,Daniel F Hayes,Arul M Chinnaiyan,Veerabhadran Baladandayuthapani,Jason Heth,Matthew B Soellner,Sofia D Merajver,Nathan Merrill

Cancer research communications（2023）

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摘要

Examining genomic alterations and differentially expressed pathways in brain metastases may inform future therapeutic strategies. This study supports genomically-guided therapy for BCBM and further investigation into incorporating real-time functional evaluation will increase confidence in efficacy estimations during drug development and predictive biomarker assessment for BCBM.

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关键词

breast cancer brain metastases,precision medicine,breast cancer

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