A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues.

Alessandra Manca,Amedeo De Nicolò,Elisa Delia De Vivo,Micol Ferrara, Sharon Oh, Sahar Khalili,Niamh Higgins,Robert G Deiss,Stefano Bonora,Jessica Cusato,Alice Palermiti,Jacopo Mula,Sara Gianella,Antonio D'Avolio

Pharmaceuticals (Basel, Switzerland)（2023）

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摘要

Results in terms of linearity, accuracy, precision, recovery and matrix effect fitted the recommendations of FDA and EMA guidelines, and the sensitivity was high enough to allow successful application on human autoptic specimens from an ethically approved clinical study, confirming its eligibility for post-mortem pharmacological/toxicological studies.

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seven opioids,uhplc-ms/ms method

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