Stimulation of Angiotensin II Type 2 Receptor Modulates Pro-Inflammatory Response in Microglia and Macrophages: Therapeutic Implications for the Treatment of Stroke.

Abdulkarim Alshammari,Yohan Han,Timothy W Jones,Bindu Pillai,Duo Zhang,Adviye Ergul,Payaningal R Somanath,Susan C Fagan

Life (Basel, Switzerland)（2023）

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摘要

Our findings suggest a protective effect of C21 against the inflammatory response, in both macrophages and microglia, via suppression of the release of pro-inflammatory cytokines/chemokines and the generation of ROS while stimulating the production of neurotrophic factors.

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关键词

stroke, neuroinflammatory response, Compound 21, renin-angiotensin system, BDNF, GDNF

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