Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review.

Ricardo A Torres-Guzman,Francisco R Avila,Karla C Maita,John P Garcia,Gioacchino D De Sario,Sahar Borna,Abdullah S Eldaly,Alfredo Quinones-Hinojosa,Abba C Zubair,Olivia A Ho,Antonio J Forte

Journal of clinical medicine（2023）

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摘要

This systematic review examined BMP and MSC synergy in biomaterial scaffolds or alone. BMP therapy and mesenchymal stem cells in calvarial defects, alone, or with a scaffold regenerated bone. This method treats skull defects in clinical trials. The best scaffold material, therapeutic dosage, administration method, and long-term side effects need further study.

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关键词

models, animal, stem cells, tissue engineering, biocompatible materials, reconstructive surgical procedures, craniotomy, neurosurgical procedures, surgery, plastic

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