The crescent-like Golgi ribbon is shaped by the Ajuba/PRMT5/Aurora-A complex-modified HURP.

Shao-Chih Chiu, Xin-Ting Yang,Tong-You Wade Wei,Yu-Ting Amber Liao,Jo-Mei Maureen Chen,Yi-Chun Kuo,Chun-Chih Jared Liu, Chiao-Yun Cheng,Yu-Ting Jenny Huang,Yun-Ru Jaoying Huang, He-Lian Joe Wu,Chang-Xin Wan, Jia-Rung Tsai,Chang-Tze Ricky Yu

Cell communication and signaling : CCS（2023）

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摘要

The Ajuba/PRMT5/Aurora-A complex integrates the signals of protein methylation and phosphorylation to HURP, and the HURP p725 organizes GA by stabilizing and recruiting GAFs to its crescent-like structure, therefore shaping GA as a crescent ribbon. Therefore, the HURP p725 fiber serves a template to construct GA according to its shape. Video Abstract.

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关键词

Golgi ribbon, HURP, Ajuba, PRMT5, Aurora-A, ARF1

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