Intrathecal CD8 + CD20 + T Cells in Primary Progressive Multiple Sclerosis.

Marina Rode von Essen,Jacob Talbot,Rikke Holm Holm Hansen,Helene Højsgaard Chow,Henrik Lundell,Hartwig Roman Siebner,Finn Sellebjerg

Neurology(R) neuroimmunology & neuroinflammation（2023）

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摘要

This study shows an association between intrathecal CD8CD20 T cells, white matter injury, and thalamic atrophy in PPMS, suggesting a role of CD8CD20 T cells in the immunopathogenesis of PPMS. The results also suggest that limited efficacy of dimethyl fumarate in PPMS may, at least partly, be a consequence of failure to suppress CD8CD20 T cells in CSF.

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关键词

multiple sclerosis,cd8<sup>+</sup>cd20<sup>+</sup>t,cells

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