Decreased circulating CD73 and adenosine deaminase are associated with disease severity in hospitalized patients with COVID-19.

Jonathan Rud,Richard R Riker,Ashley Eldridge,Christine Lord,Joanne T deKay,Teresa L May,David J Gagnon,Douglas Sawyer,Sergey Ryzhov,David B Seder

International journal of immunopathology and pharmacology（2023）

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摘要

Our study indicates that adenosine metabolism is down-regulated in patients with COVID-19 and associated with severe infection. Further large-scale studies are warranted to investigate the role of the adenosinergic anti-inflammatory CD73/ADA axis in protection against COVID-19.

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adenosine deaminase,disease severity,patients

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