The association of prediabetes and type 2 diabetes with hippocampal subfields volume: The Maastricht study.

Jennifer Monereo-Sánchez,Jacobus F A Jansen,Sebastian Köhler,Martin P J van Boxtel,Walter H Backes,Coen D A Stehouwer,Abraham A Kroon,Jeroen P Kooman,Casper G Schalkwijk,David E J Linden,Miranda T Schram

NeuroImage. Clinical（2023）

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摘要

Type 2 diabetes and measures of hyperglycemia are associated with hippocampal subfield atrophy, independently of lifestyle and cardiovascular risk factors. We found evidence for a dose-response relationship from normal glucose metabolism, to prediabetes, to type 2 diabetes. Prediabetes stages could give a window of opportunity for the early prevention of brain disease.

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关键词

Brain atrophy,Glucose metabolism,Hippocampal subfields,MRI,Prediabetes,Type 2 diabetes

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