Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment.
Phytomedicine : international journal of phytotherapy and phytopharmacology(2023)
摘要
Our results indicate that the inhibition of FABP4 activity by AP explains the anti-OA properties of Andrographis paniculata by protecting against cartilage degradation in OA patients. Additionally, our findings suggest that AP may be a promising therapeutic agent for OA treatment due to its ability to alleviate cartilage damage and bone erosion.
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关键词
novel fabp4 inhibitor,osteoarthritis,andrographolide
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