Cerebral glucagon-like peptide-1 receptor activation alleviates traumatic brain injury by glymphatic system regulation in mice.

Chuanxiang Lv,Shuai Han,Zhuang Sha,Mingqi Liu,Shiying Dong,Chunyun Zhang,Zean Li,Kang Zhang,Shouyong Lu, Zhiyang Xu,Li Bie,Rongcai Jiang

CNS neuroscience & therapeutics（2023）

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摘要

Cerebral GLP-1R activation can effectively ameliorate neuropathological changes and cognitive impairment following TBI; the underlying mechanism could involve the repair of the glymphatic system damaged by TBI.

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关键词

cognitive impairment, glucagon-like peptide-1 receptor, glymphatic system, traumatic brain injury

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