OP2113, a new drug for chronic hypoxia-induced pulmonary hypertension treatment in rat.

Lukas Roubenne,Margaux Laisné,David Benoist,Marilyne Campagnac, Bénédicte Prunet,Philippe Pasdois,Guillaume Cardouat,Thomas Ducret,Jean-François Quignard,Pierre Vacher,Isabelle Baudrimont,Roger Marthan,Patrick Berger,Bruno Le Grand,Véronique Freund-Michel,Christelle Guibert

British journal of pharmacology（2023）

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摘要

Our study provides evidence for a selective protective effect of OP2113 in vivo on alterations in both PA and RV from CH-PH rats without side effects in control rats.

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关键词

oxidative stress, pulmonary circulation, pulmonary hypertension, right ventricle

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