Focal to Bilateral Tonic-Clonic Seizures Predict Pharmacoresistance in Focal Cortical Dysplasia-Related Epilepsy.

Phat Chang,Hua Xie, Venkata Sita Priyanka Illapani,Xiaozhen You,Tayyba Anwar, Archana Pasupuleti, Thuy-Anh Vu, L Gilbert Vezina,Taha Gholipour,Chima O Oluigbo,Anqing Zhang,William Davis Gaillard,Nathan T Cohen

Epilepsia（2023）

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摘要

In a heterogeneous population of surgical and non-operated patients with FCD-related epilepsy, the presence of FTBTC seizures is associated with a tremendous risk of PRE. This finding is a recognizable marker to help neurologists identify those children with FCD-related epilepsy at high risk of PRE, and can flag patients for earlier consideration of potentially curative surgery. FCD dominant network also contributes to FTBTC seizure clinical expression.

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关键词

tonic–clonic seizures,epilepsy,focal cortical dysplasia–related,bilateral tonic–clonic,pharmacoresistance

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